Abstract
METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF VALSARTAN AND CILNIDIPINE IN TABLET DOSAGE FORMS BY RP-HPLC
*Amreen, G. Kumaraswamy and R. Lalitha
ABSTRACT
The proposed Research work is simple, precise and accurate RP-HPLC method was developed for the simultaneous estimation of Valsartan and Cilnidipine. The current RP-HPLC method utilizes stationary phase and consists of symmetry C18 (250 × 4.6 mm, 5 ?m in particle size) with a mobile phase comprising of Methanol : Pottassium di hydrogen Phosphate buffer (80:20%v/v) pH 3.5 adjusted by Orthophopharic acid at a flow rate of 1.2 mL/min, column temperature of 25 °C and UV detection at 260 nm. The retention time of Valsartan and Cilnidipine were 2.05 and 5.13 min respectively. The linearity was found to be in the range of 10–60 g/mL and 5– 30 ?g/mL for Cilnidipine and Valsartan respectively. The % recovery was found to be 99.76 ± 0.426 for Cilnidipine and 98.93 ± 0.1020 for Valsartan. The proposed method was validated as per ICH guidelines and successfully applied for the determination of drugs in tablet.
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