World Journal of
Pharmaceutical and Life Sciences

EVALUATION OF ANALGESIC ACTIVITY OF ETHANOLIC EXTRACT OF MOMORDICA TUBEROSA LEAVES IN EXPERIMENTAL ANIMALS

Dr. Yasmeen A. Maniyar and Dr. Jayapradha S. Totad*

ABSTRACT

Pain is a disabling accompaniment of many medical conditions. It is direct response to an untoward event associated with tissue damage, such as injury, inflammation or cancer. Momoradica tuberosa has been recognized as traditional medicine for the treatment of different diseases. Objectives: The aim of the present study was to evaluate the analgesic activity of ethanolic extract of Momordica Tuberosa leaves (EEMTL) in experimental animals. Methods: The study was designed to evaluate the peripheral and central analgesic activity of EEMTL (250mg/kg, 500mg/kg body weight p.o) by using 0.7% acetic acid induced writhing test and radiant heat tail flick method in mice and rats respectively. Aspirin is used as the standard drug. The mean reaction time and number of writhings were measured. Results: EEMTL significantly decreased the number of writhing and produced 60.89% of inhibition at 500mg/kg bw(p<0.0001)which was comparable with that of the standard drug aspirin (p<0.0001) in writhing test. It also showed increase in the mean reaction time in tail-flick method (p<0.0001) at all the doses at 1st,2nd and 3rd hr. EEMTL produced significant tail flick latency and percentage inhibition of writhing response at all the doses in contrast to control group. Conclusion: EEMTL has significant peripheral and central analgesic activity.

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