World Journal of
Pharmaceutical and Life Sciences

CHEMISTRY AND PATHOPHYSIOLOGY OF 2–PHENYL–4H–CHROMEN–4–ONE DERIVATIVES AS HOLISTIC FLORA IN THE FORM OF GLYCOSIDIC AGLYCONE

*Arpita Biswas, Prof. Dr. Badmanaban R., Prof. Dr. Dhrubo Jyoti Sen and Prof. Dr. Beduin Mahanti

ABSTRACT

Flavones are flavonoids characterized by a nonsaturated 3–C chain and have a double bond between C–2 and C–3, like flavonols, with which they differ by the absence of hydroxyl in the 3–position. It appears that this simple difference in structure between flavones and flavonols has very important consequences in the biogenesis, physiological, and pharmacological roles, and the phylogenetic and chemotaxonomic signification of these compounds. Flavones are widely distributed among the higher plants in the form of aglycones of glycosides. Flavonols are molecules present in most plants that are an important component of some human diets. Epidemiological evidence shows the beneficial effects of these molecules in cardiovascular and neuropathological diseases. Experimental evidence in–vitro and in–vivo has confirmed the neuroprotective effects in neurons in culture against oxidative insults and in models of focal ischemia and experimental parkinsonism. Nevertheless, the active concentration range in–vitro is very narrow, and effects on brain pathology have been shown mostly after chronic administration. Although the preventive effects of flavones and flavonols in brain pathology could be considered mostly substantiated, the positive neuroprotective activity after acute administration still deserves more research.

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