World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

PARATHYRIN IMPROVES GLUCOSE METABOLISM

Dr. Moisa S. S.*

ABSTRACT

The review contains contemporary and retrospective literature data about parathyrin effect and its interaction with calcium channel blockers concerning to glucose metabolism. It is shown that parathyrin decreases the blood glucose basal level, decreases the degree of hyperglycemia under glucose load, doesn’t effect on insulin-stimulated glucose consumption by the muscle and adipose tissues in vivo and in vitro, increases glucose tolerance, i.e. parathyrin is gluco-regulating hormone. Calcium channels blockers (isoptin and nifedipin) led to much more decreasing of hyperglycemia under glucose-tolerance test against the background of parathyrin. It indicates the role of L-type Ca2+-channel in the mechanisms of parathyrin effect on glucose homeostasis and testifies about parathyrin capacity to increase glucose tolerance.

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