World Journal of
Pharmaceutical and Life Sciences

LECITHIN-POLOXAMER BASED NANOFOMULATION FOR OPHTHAMIC DELIVERY

Bhagwat Lodhi, Priyanka Rathore, Surendra Jain, Durga Pandey*

ABSTRACT

Nanoemulsion can be defined as oil-in-water (o/w) emulsions with mean droplet diameters ranging between 100 and 500 nm, terms sub-micron emulsion and mini-emulsion are used as synonyms. The aim of the present study is to investigate the potential of a nanoemulsion formulation for ocular delivery of Ofloxacin. Our aim is to develop and characterize the nanoemulsion bearing antimicrobial drug for improvement of drug absorption from precorneal area. Our developed delivery system will result with improved drug retention in precorneal area and antimicrobial efficacy. Oil in water nanoemulsion prepared by using lecithin as surfactant and pluronic F-68 as co surfactant with the help of high shear stirring. Formulation optimized on the basis of their size and stability. FTIR confirmed that drug is Ofloxacin. Melting point of drug was found 246-248°C, Particle size was found less than 500 nm, Viscosity of optimized formulatipon was 3. pH was 7.1 Entrapment of drug was found ~70%. Sustained release formulation was achieved with 59.43 % release in 24 hrs. Formulaton was observed visually for phase preparation and creaming and found stable up to three months. No phase separation observed.

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