World Journal of
Pharmaceutical and Life Sciences

ORAL IN-SITU GEL: A REVIEW

D. S. Pawar*

ABSTRACT

The difficulties in oral drug delivery system prompted the researchers to design a drug delivery system which can stay in the stomach for prolonged and predictable time. One novel approach in this area is gastroretentive floating drug delivery system. Oral in-situ gel forming system provided a suitable way of providing the controlled delivery of drug within the stomach with enhanced gastric retention. This gives benefit of increased residence as well as sustained release. In-situ gel gives advantages such as ease of administration, reduced frequency of administration, improved patient compliance and comfort. In-situ gel formation occurs due to one or combination of different stimuli such as PH change, temperature modulation and ionic cross linking. In-situ gels are the solutions that undergo gelation after reaching the particular site due to physico- chemical changes. The gel formed from in-situ gelling system, being lighter than gastric fluids float over stomach contents due to the presence of bio adhesive nature of polymers resulting in prolonged gastric retention time.

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