World Journal of
Pharmaceutical and Life Sciences

PHYSICAL CHARACTERISTICS OF TABLET COMBINING GRANULES WITH DUTCH TEAK EXTRACT (GUAZUMA ULMIFOLIA (L).) AND GREEN TEA EXTRACT (CAMELIA SINENSIS (L.) O.K) WITH AVOCADO STARCH (PERSEA AMERICANA MILL.) AS BINDING AGENT

Wardiyah* and Tati Suprapti

ABSTRACT

Dutch teak Guazuma ulmifolia (L.) and green tea (Camelia sinensis (L.) O.K) are known for their use as antiobesity agents. The Dutch teak and green tea extract are produced through remaseration using 70% of alcohol. Avocado seed contains amylose and amylopectin compounds. Amylose content enables the extract to absorb water and has a good expanding capacity, which makes it possible to be employed as tablet break-apart agent. Amylopectin on the other hand, has the ability to form aggregate through inter-particle binding, therefore, it serves as a binding agent. The research is aimed at understanding the effect of avocado starch as a binding agent toward tablet’s physical characteristics, including weight homogeneity, hardness, friability, and break-apart time. Tablet is produced through wet granulation process with avocado starch as the binding agents (on 4 formulas) and two other agents, serving as control agent, namely PVP and gelatin. The obtained data is analyzed theoretically by comparing the result with the existing literature and statistically employing ANOVA one-way test, with 95% level of trust. Tablet with the best quality is produced from formula group of avocado starch with 5% concentration. As the concentration of avocado starch goes up, the flow time also runs up, as well as the humidity level, hardness and break-apart time on granule, Dutch teak extract, and green tea extract. A significant difference among the six formula occurs on the test of hardness, friability, break-apart time, and some size homogeneity tests, which is indicated by the value of p < 0.05.

[Full Text Article]   [Download Certificate]