World Journal of
Pharmaceutical and Life Sciences

A REVIEW ON: SOLID DISPERSIONS USING CARRIERS SUCH AS SUPER-DISINFECTANTS AND SURFACTANTS.

Uditi Handa, Kamal Saroha* and Rohini Rana

ABSTRACT

The solubility behavior of the drugs remains one of the most challenging aspects in formulation development & it is key determinant to its oral bioavailability & it is the rate limiting step to absorption of drugs from G.I.T. This results in important products not reaching the market or not achieving their full potential. Solid Dispersion has attracted considerable interest as an efficient means of improving the solubility, dissolution rate & bioavailability of hydrophobic drugs. This strategy has proven to improve the bioavailability by dispersing the class II & IV drug as very fine particles within hydrophilic matrix that results in increased solubility with increased surface area available for dissolution. This article reviews the need for the solubility enhancement of poorly water soluble drugs, historical background, advantages, disadvantages, various categories of solid dispersions, manufacturing methods, superdisintegrants and surfactants polymers characterization of solid dispersions.

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