World Journal of
Pharmaceutical and Life Sciences

FORMULATION AND INVITRO EVALUATION OF BUCCAL TABLETS OF PRAVASTATIN

M. Leela Bhavani* and D. Dhachinamoorthi

ABSTRACT

In the present study, an attempt was made to prepare Buccal tablets of Pravastatin HCL (HMG-CoA reductase inhibitors), in order to overcome bioavailability problems, to reduce dose dependent side effects Buccal tablets containing the Pravastatin HCL were prepared by direct compression method using combinations of polymers (such as Sodium alginate, Guar gum & Xanthan gum). Estimation of Pravastatin HCL were carried out spectrophotometrically at 240 nm. The Buccal tablets were evaluated for various physical and biological parameters, drug content uniformity, in-vitro drug release, drug- excipient interactions (FTIR). IR spectroscopic studies indicated that there are no drug-excipient interactions. The formulations F9 (containing 40mg of Guar gum) were found to be promising, which showed maximum drug release within 8 h. These formulations have displayed good bioadhesion strength (4.72 gm respectively).

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