World Journal of
Pharmaceutical and Life Sciences

A REVIEW ON DIABETES INDUCED MEMORY IMPAIRMENT

Priyanka*, Chitra Gupta and Somya Sah

ABSTRACT

AD is a progressive neurotic degenerative brain disorder that occurs gradually and results in memory loss, unusual behaviour, personality changes. Diabetes is a group of complex metabolic disease characterized by hyperglycemia. The development of cognitive dysfunction in patient with diabetes includes many hypothesis include potential causative role of hyperglycemia, vascular disease, insulin resistance, hypoglycaemia and amyloid deposition. AGE’S are considered significant biomarkers of oxidative stress and markers of carbonyl stress which occur due to an amplified level of sugars and reactive dicarbonyl compounds. Metformin is an oral biguanide, generically available diabetes drug that is the first line treatment for type 2 diabetes. there is confirmation from clinical studies that metformin does cross the BBB and activates AMPK in CNS tissue. In nerve cell lines, contact to metformin sensitizes neurons to insulin and also prevents memory impairment pathology in neurons chronically exposed to a hyperinsulinemic environment.

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