World Journal of
Pharmaceutical and Life Sciences

EVALUATION OF ANTI-DEPRESSANT ACTIVITY OF ETHANOLIC ROOT EXTRACT OF ANNONA SQUAMOSA L

Y. Anil Kumar, T. Mahesh SSN*, P. Kalpana, T. Sai Aparna Tejaswini and Dr. Konda Ravi Kumar

ABSTRACT

This work has been done for the investigation of the anti-depressant activity of Ethanolic root extract of Annona squamosa (EREAS) belongs to the family Annonaceae by oral administration at dose according to the body weight in a sequential manner in healthy albino rats. Extracts were studied for its anti-depressant activity by using Imipramine as standard drug. Forced swim test (FST) and Tail suspension tests (TST) are used for the study. Imipramine decreases the immobility time of the animals. Plant extract given in three doses (100, 200 and 300mg/kg) were in a dose dependent manner. 300mg/kg plant extract showed decreased immobility time near as to that of the standard drug. The decrease in immobility period in both the models was observed starting from 200 mg/kg. But the increase in dose from 200 to 300 mg/kg produces further reduction in immobility period. At the dose 100 & 200mg/kg, ASRE showed a little antidepressant effect when comparable to that of Imipramine. At the dose 300 mg/kg, ASRE showed antidepressant effect which is comparable to that of Imipramine. This evaluation may suggest that the antidepressant action is because of the possible involvement of either nor-adrenergic or serotonergic system.

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