World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

ISOLATION OF A DIHYDROFLAVONOL FROM SUDANESE SMILAX REGELII (SMILACACEAE) AND ANTIMICROBIAL POTENTIAL OF ITS FRACTIONS

Mohamed A. M., Mayads I.*, Weam A. K.

ABSTRACT

The ethanol extract of Smilax regelii was purified by thin layer chromatography where a flavonoid - compound I - was isolated and partially characterized by spectral data (UV, 1HNMR). The ethanol extract and the chloroform, ethyl acetate, n-butanol fractons were screened for antimicrobial activity against: Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis, Staphylococcus aureus and the yeast Candida albicans. The ethyl acetate, chloroform, n-butanol and ethanol fractions showed significant activity against Staphylococcus aureus, while the n-butanol and ethyl acetate fractions exhibited significant inhibitory effect against Bacillus subtilis.

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