World Journal of
Pharmaceutical and Life Sciences

AN OUTBREAK OF CHIKUNGUNYA FEVER IN DHAKA CITY: CLINICAL PRESENTATION AND SHORT TERM OUTCOME

Quazi Tarikul Islam, Md. Mahmudur Rahman Siddiqui* and Abdul Basit Ibne Momen

ABSTRACT

Objective: Clinical manifestations of chikungunya fever are variable and ranges from abrupt onset fever, skin rashes, arthralgia, arthritis, vomiting, diarrhea, minor haemorrhages to severe manifestations like encephalitis, optic neuritis, seizures, acute flaccid paralysis etc. In 2017, Bangladesh experienced a large outbreak of Chikungunya just in early-monsoon in March when there was unexpected rainfall. This original article is published to give an idea about this recent outbreak. Methods: The study was carried out during a fever outbreak between early April to September 2017 in Dhaka city of Bangladesh. The data, sample collection, and clinical examination of 257 Chikungunya fever positive patients were included in this study. Results: Out of 257 cases, 167(65%) were female and 89(35%) were male. Majority 23.34% patients were in 3rd floor in their residence followed by 20.62% on the 1st floor. 39.29% patients presented to the doctor on the 4th day of fever, 29.18% on the 3rd day, 18.28% on the 5th day. Skin rashes were present in 67% of cases. Backache was in 24% of cases. Highest recorded temperature was 1030F in 36% cases, followed by 1040F in 34%. 56.03% patients presented with the involvement of both small and large joints, 37.35% presented with only large joint involvements and 6.61% only small joints involvements. They also had associated other features like; Headache in 79.37%, nausea & vomiting in 77.43%, lymphadenopathy in 5.44%, cough in 5.05% and pain abdomen in 1.5% cases. 131(50.97%) presented with sub-acute phase, 124(48.24%) acute phase and only 1(0.38%) chronic phase. The outcome of joint pain after 6 months showed 156(61%) have no residual joint pain but 94(36%) patients presented with persistent joint pain. Of these 257 patients, 7(3%) patients died within this periods. Conclusion: This study was carried out to characterize the epidemiological, clinical parameters along with outcomes in all cases of chikungunya positive patients during 2017 epidemic of chikungunya in Dhaka city. We think it will help to study further about this infectious disease.

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