World Journal of
Pharmaceutical and Life Sciences

ELEVATED SECOND TRIMESTETR SERUM β-hCG LEVEL AS PREDICTOR OF PREECLAMPSIA

Prof. Ali Hassan Mohammed*

ABSTRACT

Aim: To find any method can predict preeclampsia before 20 weeks gestation to take our precaution to these pregnants as high risk pregnancy. Study: This is a cohort study conducted on 96 primigravida with singleton pregnancies at their second trimester period to study the value of elevated serum ?-human chorionic gonadotropin in predicting development of preeclampsia. Objective: We looked for the differences in serum ?-hCG levels between pregnant women with pregnancy induced hypertension and pregnant women with normal pressure. We also studied the predictive value of such assays. Methods: We took a blood (serum) from 100 (4 was escape) pregnant lady between 14-20 weeks gestation and test their serum for B-hCG and follow them by signs and physical examinations and investigations for any idea related for preeclampsia till delivery and 2 week post partum period (really we sticky the pregnants by downing all these investigations and examinations freely in especially highly expensive tests and follow up all was freely from any fees. Result: Pregnancy induced hypertension was found in 9 in a population of 96 nulliparous. ?-hCG levels were significantly higher in women who later developed hypertension (30,000 IU/L – 50,000 IU/C versus 15,650 – 25,620 IU/L). In nulliparous taking 29,250 IU/L as a cut off value of pathology we found that the predictive value of ?-hCG was higher [sensitivity (66.7%, specificity (98.9%), positive predictive value (85.7%), negative predictive value (96.7%)], these values can be changed by changing the cut off point for positive test results. Taking a cut off value more than 32,000 IU/L it was possible to predict the occurrence of pregnancy induced hypertension more precisely. Conclusion: the mid trimester high serum B-hCG is good predictor for early detection of preeclampsia later on.

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