World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

A SIMPLE UV SPECTROSCOPIC METHOD DEVELOPMENT AND VALIDATION FOR THE QUANTIFICATION OF SIMVASTATIN IN BULK AND ITS FORMULATION

A. Padma*, Dr. K. Thejomoorthy, B. Snehith, Mala Prashanth Kumar, Nandini Tumma

ABSTRACT

A simple, rapid, accurate, precise, selective and economical UV Spectrophotometric method has been developed for estimation of Simvastatin in bulk and its dosage form. Ethanol 30% v/v was used as diluent for the study. The maximum absorption was monitored at 238 nm. The method exhibited linearity in the concentration range of 5- 30?g/ml with correlation coefficient value 0.999. The accuracy of the method was checked at three different levels of 50%, 100% and 150 %. The % recovery was found to be 100.18%. The developed method was validated with respect to accuracy, precision, selectivity, specificity and robustness. All the parameters examined were within the acceptance limits.The above method was a cost-effective quality control tool for routine analysis of Simvastatin in bulk and its pharmaceutical dosage form.

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