World Journal of
Pharmaceutical and Life Sciences

GC-MS ANALYSIS AND ANTIMICROBIAL ACTIVITY OF SUDANESE GREWIA TENAX FORSSK (TILIACEAE) FIXED OIL

Abdel Karim M.*, Abdel Azim I. and Sufian A.

ABSTRACT

Grewia tenax is a small tree which is prevalent in Africa and south-east Asia. Grewia tenax has a wide distribution in north and middle Sudan. This plant is a key species in Sudanese ethnomedicine. In this work Grewia tenax seed oil was studied by GC-MS. The oil was also assessed for antimicrobial activity. The GC-MS analysis showed 12 components dominated by: 9,12-octadecadienoic acid methyl ester (51.69%); hexadecanoic acid methyl ester(18.83%); 9-octadecenoic acid methyl ester(16.41%) and methyl stearate(9.33%). The antimicrobial activity of the oil was evaluated via the diffusion bioassay against five standard pathogenic bacteria (Gram positive: Staphylococcus aureus and Bacillus subtitlis; Gram negative : Esherichia coli and Pseudomonasa aeruginosa and the fungus Candida albicans). The oil showed significant antibacterial activity against Staphylococcus aureus.It also showed significant anticandidal activity. However, it exhibited partial activity against Pseudomonas aeruginosa and Escherichia coli.

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