World Journal of
Pharmaceutical and Life Sciences

ORAL MISOPROSTOL VERSUS OXYTOCIN IN THE MANAGEMENT OF THIRD STAGE OF LABOUR

Rashi Rashi*, Sipra Singh and Soma Bandopadhyaya

ABSTRACT

Objectives: To compare oral misoprostol versus intramuscular oxytocin in the management of third stage of labour. Methods: The quasi-experimental study was conducted at the Department of Obstetrics & Gynecology, Katihar Medical College and hospital, Katihar, Bihar from Januaary 2017 to June 2017, after approval of the study by institute ethical committee. One hundred women attending the labor ward were included after taking informed consent. A total of 100 patients diagnosed in active phase of labour who fulfilled the inclusion criteria were selected by non-probability convenience sampling. These patients were divided into 2 groups of 50 patients each, for Oxytocin (Group 1) and misoprostol (Group 2). Main and secondary outcome measures were analysed. SPSS 10 was used for statistical analysis. Results: Average amount of blood loss(ml) was 267.14±140.35 with Oxytocin versus 302.86±160.4, with Misoprostol, this difference was statistically insignificant (p=0.236). Average drop in haemoglobin concentration (g/dl) with Oxytocin was 1.55±0.38 vs 1.66±0.61 with Misoprostol (p=0.684). Drop in haematocrit (%) was 4.18±0.64 with Oxytocin vs. 4.50±0.92 with Misoprostol (p=0.133). There was also insignificant difference in duration of third stage of labour, between oxytocin and Misoprostol groups (5.37±2.20 vs. 5.23±2.46, p=0.451) Shivering, in Misoprostol group occured in n=11 (31.4%) vs n=3 (8.6%) with Oxytocin (p=0.017) and pyrexia in n=6 (17.1%) with misoprostol vs n=0, with oxytocin (p=0.025) thus significantly higher in misoprostol group. Conclusion: There were no major differences in oral misoprostol and intramuscular oxytocin in the management of third stage of labour.

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