World Journal of
Pharmaceutical and Life Sciences

EFFECTIVENESS OF WOUND TREATMENT WITH JUBIRKURILAH EXTRACTS IN RATS (RATTUS NORVEGICUS)

Masnun and Dr. Tonny C. Maigoda*

ABSTRACT

The aim of this study was to identify the effectiveness of mixed extracts namely: dringo plant/jurangau (Acorus calamus), gambier/gambir (Uncaria), cassumunar ginger/kunyit bolai (Zingiber purpureum), betel leave/sirih (Piper betle linn), and black pepper/lada hitam (Piper nigrum) which is abbreviated as Jubirkurihlah toward the incision wound healing in rats (Rattus norvegicus). This research is quantitative research by using experimental research design. The samples were 45 of Rattus norvegicus in which 15 rats were treated by the extract of 15%, 15 rats were treated by the extract of 20%, and 15 rats were treated by the extract of 25%. The incision was as deep as 2 mm with 1 cm length on the back, then the wound was treated with Jubirkurihlah extract (15%, 20%, 25%) once a day and observed for infection mark until the wound healed. The results of the study found that there were no sign of infection on the three treatment groups, the average of wound healing time treated by the extract of 15% was 5.66 days, the extract of 20% was 3.84 days, and the extract of 25% was 3.43 days. The difference level in the length of wound healing time between the extract of 15% compared to the extract of 20% was found p value as much as 0.0049 (there was a significant difference level between the extract of 15% and the extract of 20%), the extract of 15% compared to the extract of 25% was found p value of 0.00165 (there was a significant difference level between the extract of 15% and the extract of 25%), the extract of 20% compared to the extract of 25% was found p value 0.318 at ? 0.05 (there was no significant difference level between the extract of 20% and 25%). Conclusion: the extract of 25% was the most effective toward the wound healing process in Rattus norvegicus. Advanced research with the extract of 25% compared to Iodine and Betadine in Rattus norvegicus is required.

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