World Journal of
Pharmaceutical and Life Sciences

FORMULATION AND EVALUATION OF COLON TARGETED DRUG DELIVERY OF SATRANIDAZOLE

P. Swetha*, Middela Karthik and Burra Mamatha

ABSTRACT

The colon is a site where both local and systemic delivery of drugs can take place. Treatment could be made more effective if it were possible for dugs to be targeted directly on the colon. Colon-specific systems could also be used in diseases that have diurnal rhythms. In the present study, attempt was made to target the drug to the colon, and intentionally giving release of the drug when it reaches to the colon. In DSC thermogram it shows there is no any possible interaction between drug and polymer.Different drug release patterns were obtained due to different polymers. The study was carried out at two different media 0.1 N HCl and phosphate buffer pH 7.4 This is due to change in gastric to intestinal pH media. For the first 2 hours the pH media was selected 0.1N HCl as gastric residence time is 2 hours then remaining study is carried out in phosphate buffer 7.4 pH media.The result of this study indicates that the Chitosan polymer dissolves above pH 6.5 so it shows burst release at pH 7.0 as compared to other polymers i.e. ethyl cellulose and HPMC. This is an important criteria in colonic drug delivery because most of the drug should be released in the colon itself and not in gastric or intestinal area. The Satranidazole- Chitosan tablet formulation after enteric coating by Eudragit S100 showed better result in physical characteristics and their in vitro drug release study.

[Full Text Article]   [Download Certificate]