World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

IN SILICO STUDIES ON DENGUE AND MEASLES VIRAL PROTEINS WITH SELECTED METHANOLIC EXTRACTS OF CORIANDER SATIVUM LEAVES CONSTITUENTS

Aniruddha B. S., Ashwini B. M., Mahesh K., Nagarjun N. and *Balasubramanian Sathyamurthy

ABSTRACT

Coriander (Coriandrum sativum L.) has been reported to have many medicinal properties. Its plant, seeds, leaves and roots are edible, although they have very distinct flavours and uses. Coriander is also well known for its antioxidant, anti-diabetic, anti-mutagenic, antianxiety and antimicrobial activity along with analgesic and hormone balancing effect. Phytochemicals present in Coriander Sativum are also found to have and antifungal properties. In this study, the binding efficiency of 4 compounds that is present in the Coriander Sativum with two structural Dengue virus proteins and four structural measles virus proteins through Insilico methods. By molecular docking result, we found that the compound Squalene and 9, 12 octadecadienoic acid (Z,Z),2-hydroxy,1(hydroxymethy) propyl ester,2,3-dihydroxy propyl ester have highest binding affinity with the chosen viral proteins.

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