World Journal of
Pharmaceutical and Life Sciences

MYCOBACTERIUM TUBERCULOSIS (MTB) RESISTANCE PATTERN TO FIRST LINE ATT

Dr. Salman Sarwar*, Sumera Zia and Bakhtawar Jabeen

ABSTRACT

Objective: To determine the Mycobacterium Tuberculosis (MTB) resistance pattern to first line Anti tuberculosis therapy (ATT). Methodology: This cross sectional study was done at Department of Pulmonology, Sheikh Zayed Hospital, Rahim Yar Khan during July to December 2017. The diagnosed cases of pulmonary TB were selected irrespective of the gender and with age range of 12 to 60 years. Sputum sample of these cases was processed at solid Lowenstein Jensen (LJ) media for at least 6 weeks, MTB isolated from these sample were then tested for their susceptibility to first line ATT. The MIC of the studied drugs per ml of LJ medium for resistance testing were 0.2 mcg for isoniazid, 02 mcg for streptomycin, , 05 mcg for Ethambutol, 100 mcg for pyrazinamide and 01 mcg for rifampicin. Results: In the present study, 50 cases were sleeted. The mean age of the cases was 43.34±8.21 years. There were 68% males and 32% females. Over all drug resistance was seen in 16 (32%) of the cases. Drug resistance was seen most commonly against streptomycin which was observed in 9 (18%) of the cases followed by Isoniazid seen in 7 (14%) of the cases. One drug resistance was seen in 12 (24%) of the cases while all 4 drug resistance was seen in 1 (2%) of the cases only. Conclusion: Drug resistance is common to first line ATT and the most resistant drug is Streptomycin.

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