World Journal of
Pharmaceutical and Life Sciences

QUALITY ASSESSMENT OF SOME ANTACID SUSPENSIONS MARKETED IN PORT HARCOURT METROPOLIS, SOUTH-SOUTH NIGERIA

Chidozie N. E. Ibezim, Chukwuekem C. Onyeka, Hanson I. Ogbu*

ABSTRACT

Sequel to health hazards and overall product spoilage, microbiologically related non-sterile products recalls abound. Thus, Pharmaceutical products must satisfy standard microbiological quality test before they are considered fit for their intended use. The aim of this study was to evaluate pharmaceutical and microbiological qualities as well as the prevalence and resistance patterns of objectionable microorganisms in antacid suspensions commonly sold in retail outlets in Port Harcourt Metropolis. Thirteen (13) brands of antacid suspensions were subjected to pharmaceutical and microbiological examinations using standard conventional techniques. The pH values of all the samples analyzed were in the alkaline range (7.43 – 9.45), while the sedimentation volume values ranged from 0.54 – 0.96. Though samples screened were uncontaminated with fungi however, objectionable organisms Escherichia coli (30.77 %) and Klebsiella pneumoniae (7.69 %) were predominant. The individual organism exhibited different patterns of resistance across the antibiotics tested. The study emphasizes the need to maintain good standards by adhering to Good Manufacturing Practice as a way of eliminating undesirable microorganism from products.

[Full Text Article]   [Download Certificate]