World Journal of
Pharmaceutical and Life Sciences

ANTI TUBERCULOSIS INDUCED HEPATITIS

Arifa Khan, Umar Raza and Dr. Aftab Alem Jehangir*

ABSTRACT

Objective: To determine the frequency of Anti Tuberculosis induced hepatitis. Methodology; In this descriptive case series study which was carried out at Medical Unit II, Sheikh Zayed Hospital, Rahim Yar Khan during August 2017 to March 2018, the cases of both genders and age range of 15 to 50 years were included. The cases were selected irrespective of the site of the TB. Pulmonary TB (PTB) was labelled according to sputum examination and radiology while the extra pulmonary TB (EPTB) was labelled according to fluid analysis i.e. pleural, peritoneal or CSF or tissue biopsy like lymph nodes. ATT was given according to WHO dosage guided program. The hepatitis was labelled as yes when the enzymes were raised 3 times above their limit with signs and symptoms or 5 times without signs and symptoms where the final outcome was seen. Results: In this study there were total 150 cases with mean age 33.44±10.11 years. There were 78 (52%) were males and 108 (72%) cases had PTB. ATT induced hepatitis was seen in 14 (9.33%) of the cases. ATT induced hepatitis was more seen in age group 15 to 31 affecting 10 (11.36%) of the cases with p= 0.04. ATT induced hepatitis was also more common in cases with PTB affecting 12 (11.11%) of the cases as compared to 2 (4.76%) of cases in EPTB with p value of 0.01 Conclusion: ATT induced hepatitis is seen in every 1/10th of the case and it is significantly high in age group 15 to 31 and those having PTB.

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