World Journal of
Pharmaceutical and Life Sciences

A REVIEW: HYDROGEL IN TOPICAL DRUG DELIVERY

Manju, Priyanka Joshi, Mohd Vaseem Fateh, N. G. Raghavendra Rao*

ABSTRACT

Topical drug delivery is the best and special route for local and systemic delivery of therapeutic agent due to its advantages and affordability. Conventional dosage forms were not able to give quick action to the desired area or system. At this stage, novel formulation like hydrogel comes into existence. Hydrogels are cross-linked polymeric three dimensional structure of hydrophilic group that can swell and shows it action due to environmental changes. Though, determining the absorption of drug at the site of action or skin layer by using topical preparations or product is a big task for researcher. Release of drug via topical route symbolize a most suitable and novel approach. Conventional topical dosages forms have not provide any evidence to be useful in topical drug delivery. Novel drug delivery systems show a great potential for topical delivery. To defeat the problems related with conventional delivery devices, polymeric gels such as hydrogels have been recommended. Hydrogels have been extensively used as the transporter for drug delivery systems. These biomaterials have increase interest due to their characteristics like swelling in aqueous solution, pH and temperature sensitivity and biocompatibility. The objective of this review article to highlights the classification of hydrogel, their advantages, disadvantages, preparation method of hydrogel, characterization of hydrogel and application of hydrogels. This review disclose the convenience of hydrogel as a topical drug delivery systems used in the body by the ophthalmic route, rectal route, vaginal route and skin.

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