World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

IN SILICO DRUG DESIGNING STUDIES ON DENGUE CAPSID PROTEIN

Sushmitha H. S., *Balasubramanian Sathyamurthy

ABSTRACT

The key proteins involved in causing dengue are the seven major proteins, which are considered as major therapeutic targets for dengue drug development. Recent studies have reported positively for capsid protein in dysregulation of causing dengue process in humans. Dragon fruit seed phytochemicals are reported to have antioxidant and antiviral properties. In the present study we studied binding efficiency of 11 compounds that are present in the dragon fruit seeds with capsid protein through Insilico methods. By our virtual screening and docking result, we found that the Compound C has the highest binding affinity with the Capsid Protein and also we predicted the binding site amino acid residues and the nature of hydrogen bonding. However more invivo experimental validation of our results with animal models will enlighten the development of more potent drugs from these compounds for treatment of dengue.

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