World Journal of
Pharmaceutical and Life Sciences

CORRELATION OF KI67 SCORE WITH OTHER PROGNOSTIC INDICATORS IN CASE OF CARCINOMA BREAST NOT UNDERGOING NEOADJUVANT CHEMOTHERAPY

*Dr. Chandan Roy Choudhury, Dr. Abhishek Sharma, Dr. Satyaprakash Kuila and Dr. Sushanta Sarkar

ABSTRACT

Aims and objectives: This study was conducted with the aim to calculate Ki67 score of all cases of breast cancer not undergoing neoadjuvant chemotherapy and correlate the score with other prognostic factors. Material and Methods: In 30 patients cases of carcinoma breast with biopsy diagnosed invasive carcinoma of breast at any age. Results and Analysis: The Ki67 score were analyzed and correlated with other prognostic indicators using standard statistical methods. The parameters namely TNM Clinical Staging, tumour size and HER-2/neu had a strong positive statistical correlation. ER, PR status had shown a statistically significant negative correlation value. The expression of Ki67 in breast cancer tissues with age and lymphovascular invasion had no significant statistical correlation. The histological grade of tumour was found to be correlated with expression of Ki67 in a positive way. Conclusion: Ki67 score can be used for prognostication and planning of treatment in patients with carcinoma breast because of its cost effectiveness and easy availability.

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