World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

THE EFFECT ON TRACE ELEMENTS OF BRAIN AND LIVER OF RAT EXPOSED TO FLUORIDE

Smita B. Patil*, Bhavana S. Pillai, Dipali D. Pillewar, and S. S. Pawar

ABSTRACT

Fluoride is a naturally occurring toxic mineral present in drinking water. Fluoride can accumulate in the body, and it has been shown that continuous exposure to it causes damaging effects on body tissues such as liver, brain and kidney. Twenty wistar albino rats were divided into four equal groups of five rats in each group. The first group of rats served as the untreated control, the second, third and fourth group was administered 0.02gm/l, 0.04gm/l, 0.06gm/l fluoride in the drinking water. After56 days, the rats were anesthetized and their brain and liver tissues were collected under ether anaesthesia for analysis of trace elements. Trace elements concentration were analysed by Atomic absorption spectrophotometer. Mn level shows significantly decreased in liver and significantly increased in brain as compared to control. And the level of Zn, Cu and Fe decreased significantly in liver and brain of rats as compared to control.

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