World Journal of
Pharmaceutical and Life Sciences

NOVEL CONCEPT IN VAGINAL DRUG DELIVERY SYSTEM: AN OVERVIEW

Abhishek Soni*, Dr. Shivali Singla, Dr. Sachin Goyal

ABSTRACT

Some drugs are poorly absorbed after the oral administration. Over the last twenty years, extensive efforts have been made towards the administration of poorly absorbed drugs through different delivery systems and routes but the presence of a mucus laden cervix (vagina) in women provides an opportunity as a conjoint site for such drug delivery. The vaginal route has been rediscovered as a potential route for systemic delivery of various therapeutically important drugs avoid first pass metabolism. However, fruitful delivery of drugs through the vagina remains a challenge because of poor absorption of some drugs across vaginal epithelium. The various factors like Vaginal Secretions, Vaginal pH, Microflora, Cyclic changes are affecting the rate of drug absorption after vaginal administration. The future of vaginal drug delivery lies in the bioadhesive tablets, liposomes, niosomes and microparticles, which although relatively new and show great promise in providing truly controlled delivery of drugs. In the current study, further attention has been made on various polymers which are used in hydrogel which provide bioadhesive property to the vaginal formulations, so that the formulation remains vaginal tissues for proper time. The main objective of the present review is to summarize various vaginal drug delivery systems with an special emphasis an vaginal anatomy and physiology, vaginal drug delivery system, factors affecting the vaginal drug absorption, Vaginal drug formulation, including the Novel concepts in vaginal drug delivery systems.

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