World Journal of
Pharmaceutical and Life Sciences

ESTIMATION OF HEPATITIS B SURFACE ANTIBODY (HBsAb) AMONG MEDICAL STUDENTS OF BINGHAM UNIVERSITY COLLEGE OF MEDICINE AND HEALTH SCIENCES, JOS

Ramyil M. S. C.*, Ike R. O., Freeman D. D., A. P. Bassi, Ogundeko T. O., Isah Y. O., Ramyil S. Mary, Janet Musa, Uzal Umar and David Numshi Musa

ABSTRACT

Background: As persistence hepatitis B virus infection has grave consequences and no satisfactory treatment is available for Medical students and health care professionals, saving themselves of this menace cannot be over emphasized. However, it is well accepted that Hepatitis B vaccination induces protective level of antibody after complete course of vaccination. This study is aimed to evaluate the immune response after completion of Hepatitis B vaccine and to reduce morbidity and mortality from HBV infection by vaccinating all clinical students in Bingham University College of Medicine and Health Sciences Jos. Methods: Rapid diagnostic test for the qualitative detection of HBsAg was conducted after a serum was obtained from blood specimen of 296 Medical students ages 19 to 30 consented for screening from December 2012 – December 2017; all reactive case to HBsAg were counseled and referred for follow-up. Hepatitis B vaccine (Euvax B) was administered to 262 at the deltoid muscles on 0, 1, and 6 months scheduled between the first and the third doses. After the third dose of vaccination, another serum specimen was collected from randomly selected 91 students and analyzed for the estimation of antibody in the individual student. Result: 5.7% prevalence of HBsAg was recorded in 296 Medical students where 14 (10.4%) males and 3 (1.9%) females with a p-value 0.0001. Then, 262 received complete vaccination while 17 had incomplete vaccination. Out of the 91 serum specimen, 94.5% had developed antibodies among which 79.12% had high, 15.38% had low and 5.49% had no-responding titers respectively. Conclusion: The study showed 94.5% developed protective level of HBsAb after four weeks of last dose vaccination. Therefore, considering the high risk for occupational hazard, all health care professionals working in the hospital environment should be given vaccines for Hepatitis B virus at the start of their career.

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