World Journal of
Pharmaceutical and Life Sciences

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
World Journal of Pharmaceutical and Life Sciences (WJPLS) has indexed with various reputed international bodies like : Google Scholar, Index Copernicus, Indian Science Publications, SOCOLAR, China, Cosmos Impact Factor, Research Bible, Fuchu, Tokyo. JAPAN, Scientific Indexing Services (SIS), Jour Informatics (Under Process), UDLedge Science Citation Index, Global Impact Factor (In Process), International Impact Factor Services, International Scientific Indexing, UAE, International Society for Research Activity (ISRA) Journal Impact Factor (JIF), Science Library Index, Dubai, United Arab Emirates, International Innovative Journal Impact Factor (IIJIF), Scientific Journal Impact Factor (SJIF), Eurasian Scientific Journal Index (ESJI), Indian citation Index (ICI), 

Abstract

FORMULATION AND EVALUATION OF ETHOSOME (MEFENAMIC ACID) USING HOT METHOD

Kamlesh Kumar Yadav* and Navneet Kumar Verma

ABSTRACT

Ethosomes are amphiphilic novel lipid vesicular systems that have shown their potential in improving the bioavailability of poorly water soluble as well as poorly lipophilic drugs. Mefenamic acid is anthranilic acid derivative agent and belongs to Biopharmaceutical classification system class II drugs that show poor water solubility as well as poor lipophilic character. Oral use of Mefenamic acid contraindicated resulting from sever side effect, thus topical administration is recommended. The present research work Ethosomal vesicles were successfully developed through hot method under stirring and sonicated and evaluated DSC thermograms, Particle size distribution, Vesicles shape, In-vitro Permeation study and Stability study. The present study demonstrates that the ethosome vesicle found to be Particle size distribution was found good. Stability study was found 97.85%, 98.69% and 98.43% as respectively. In vitro drug release 94.509%, 95.957% and 88.068% respectively as per formulation (MET1, MET2, and MET3). The entrapment of drug in vesicles found to be 57.98%, 67.26% and 33.19 % respectively, solubility and availability of drug at the site.

[Full Text Article]

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