World Journal of
Pharmaceutical and Life Sciences

PATTERN OF ANTIBIOTIC USE AND THEIR RESISTANCE IN PATIENTS ADMITTED IN ICU

Rawshon Ara Parveen*, Morshed Nasir, Afm Mohibur Rahman, Tahmina Zahan, Mohammad Ashfaqur Rahman

ABSTRACT

Prevalence of antibiotic consumption is high in critically ill patients. Besides of its economic impact, there is a chance of delayed diagnosis, difficulties in identifying causative microorganisms and the constant threat of induction of development of antibiotic resistance worsens the present situation. To analyze antibiotic consumption, antibiotic use was recorded in admitted patients in ICU during six month period by categorizing the indications for antibiotic use in both infectious and non-infectious disease in to two groups; (i) Empirical; (ii) Therapy for a bacteriologically proven infection (BPI). Among 216 patients admitted in ICU in the study period 144 cases are infectious and 72 are non- infectious. Length of stay less than 72 hours in ICU, Most of the patients (n= 133) received empirical antibiotic therapy. Staphylococcus Aureus, Acenetobactor and Pseudomonus are commonly found organism. Ceftriaxone, Meropenem and Levofloxacin were frequently used antibiotics in infectious and non- infectious cause. Antibiotic resistant shows in penicillin and cephalosporin group, whereas imipenem and meropenem were sensitive antibiotics. It may be concluded that monotherapy in non- infectious case was probably the most effective mode to reduce antibiotic use.

[Full Text Article]   [Download Certificate]