World Journal of
Pharmaceutical and Life Sciences

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
World Journal of Pharmaceutical and Life Sciences (WJPLS) has indexed with various reputed international bodies like : Google Scholar, Index Copernicus, Indian Science Publications, SOCOLAR, China, Cosmos Impact Factor, Research Bible, Fuchu, Tokyo. JAPAN, Scientific Indexing Services (SIS), Jour Informatics (Under Process), UDLedge Science Citation Index, Global Impact Factor (In Process), International Impact Factor Services, International Scientific Indexing, UAE, International Society for Research Activity (ISRA) Journal Impact Factor (JIF), Science Library Index, Dubai, United Arab Emirates, International Innovative Journal Impact Factor (IIJIF), Scientific Journal Impact Factor (SJIF), Eurasian Scientific Journal Index (ESJI), Indian citation Index (ICI), IFSIJ Measure of Journal Quality, International Scientific Indexing, UAE (ISI), 

Abstract

A STUDY ON COMPARATIVE ANALYSIS OF WITHANIA SOMNIFERA (ASHWAGANDHA) WITH VALERIANA WALLICHI (TAGARA) IN RELATION TO THEIR ANTI-INFLAMMATORY ACTIVITY IN MALE ALBINO RATS

Dr. P. Jagadeesh, Dr. M. Veera Sekhar*, P. Lakshmi Deepika and Dr. P. Vijayalakshmi

ABSTRACT

Aim and objectives: the present study was carried out 1) To evaluate the anti-inflammatory activity of Withania Somnifera, Valeriana wallichi in male albino rats. 2) To compare the anti-inflammatory activity of Withania Somnifera with Valeriana wallichi in male albino rats by using Plethysmograph. Materials and methods: Male albino wistar rats of 250 to 300gm weight were randomly allotted into three groups namely Control, Test-1 and Test-2. For control group rats 0.2 ml of normal saline, for test-1 group rats Withania Somnifera in a dose of 25.69 mg/kg, for test-2 group rats Valeriana wallichi in a dose of 120mg/kg, was administered as a single oral dose half an hour before injecting 0.1ml of 1% carrageenan to the sub-plantar region of hind paw and the paw edema of each rat was measured at 3hours Results: Both the test drugs have shown significant anti-inflammatory activity (p<0.05). However Withania somnifera in a dose of 25.69 mg/kg showed significantly higher anti-inflammatory effect than V.wallachi given in a dose of 120mg/kg. Conclusion: Withania somnifera and Valeriana wallachi have significant anti-inflammatory activity.

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