World Journal of
Pharmaceutical and Life Sciences

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
World Journal of Pharmaceutical and Life Sciences (WJPLS) has indexed with various reputed international bodies like : Google Scholar, Index Copernicus, Indian Science Publications, SOCOLAR, China, Cosmos Impact Factor, Research Bible, Fuchu, Tokyo. JAPAN, Scientific Indexing Services (SIS), Jour Informatics (Under Process), UDLedge Science Citation Index, Global Impact Factor (In Process), International Impact Factor Services, International Scientific Indexing, UAE, International Society for Research Activity (ISRA) Journal Impact Factor (JIF), Science Library Index, Dubai, United Arab Emirates, International Innovative Journal Impact Factor (IIJIF), Scientific Journal Impact Factor (SJIF), Eurasian Scientific Journal Index (ESJI), Indian citation Index (ICI), 

Abstract

PHYSICAL CHARACTERISTICS AND STABILITY MUCOADHESIVE MICROGRANULES OF RANITIDINE HCL WITH ALOE VERA POWDER POLYMER AND CARBOPOL 934P IN TEMPERATURE 2°C AND 25°C

Endang Diyah Ikasari*, Intan Martha Cahyani and Aulia Wulandari

ABSTRACT

Ranitidine HCl has low stability due to its hygroscopic. Stability tests need to determine the changes physical and chemical stability that occur during storage against. A study was conducted to determine the effect of storage temperature (2°C and 25°C) on the stability of the mucoadhesive microgranules ranitidine HCl over a period of 3 months. The mucoadhesive polymer used was a combination of aloe vera powder and carbopol 934P. Aloe vera powder was made by dried process using freeze dryer at -45ºC. The method of making granules used is wet granulation. The parameters tested included moisture, flow rate, flux, mucoadhesive power in vitro, dissolution, permeation, and SEM (Scanning Electron Microscopy). Data analysis using Statistic Product and Service Solution (SPSS) 16.0 with one way ANOVA test. The test results was showed that temperature and storage time affect the stability of microgranules because the release rate constant is significantly different throughout the test. Storage of microgranules stable at 2°C, because from 0 to 3 months which shows different results are not significant.

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