World Journal of
Pharmaceutical and Life Sciences

ROLE OF MICRO RNAS AND ITS REGULATION FOR MYCOBACTERIAL INFECTIONS

Mohammed Meeran Mohiuudin* and Anas Rasheed

ABSTRACT

Genomic studies revealed that numerous portions of the human genome do not encode conventional proteincoding genes but encode biologically active non-coding RNA species. With the rapid expansion of small RNA interference techniques over the past decade, it is now clear that many small RNA molecules could regulate gene and protein expression. One class of such small noncoding RNAs is microRNAs (miRNAs), a group of regulatory RNAs of 19–22 nucleotides involved in control of gene expression at the post-transcriptional level.[1] thereby acting as RNA interfering (RNAi) molecule. While a wellknown RNAi molecule, small interfering RNA (siRNA), is a small RNA that is artificially synthesized, miRNA exists endogenously in the cell. Therefore, miRNAs represents an innate gene-silencing mechanism in our bodies.

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