World Journal of
Pharmaceutical and Life Sciences

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
World Journal of Pharmaceutical and Life Sciences (WJPLS) has indexed with various reputed international bodies like : Google Scholar, Index Copernicus, Indian Science Publications, SOCOLAR, China, Cosmos Impact Factor, Research Bible, Fuchu, Tokyo. JAPAN, Scientific Indexing Services (SIS), Jour Informatics (Under Process), UDLedge Science Citation Index, Global Impact Factor (In Process), International Impact Factor Services, International Scientific Indexing, UAE, International Society for Research Activity (ISRA) Journal Impact Factor (JIF), Science Library Index, Dubai, United Arab Emirates, International Innovative Journal Impact Factor (IIJIF), Scientific Journal Impact Factor (SJIF), Eurasian Scientific Journal Index (ESJI), Indian citation Index (ICI), IFSIJ Measure of Journal Quality, International Scientific Indexing, UAE (ISI), 

Abstract

SPECIMENS AND GRAM-NEGATIVE BACTERIA ETIOLOGIES OF INFECTIOUS DISEASES IN A SEMI-URBAN AREA IN WEST-CAMEROON: A TWELVE-MONTH RUNDOWN OF INFECTION SCREENING IN THE MEDICAL SCHOOL TEACHING HOSPITAL

Pierre René Fotsing Kwetche*, William Lelorel Nankam Nguekap, Christelle Domngang Noche, Anselme Michel Yawat Djogang, Sandrine Gamwo, Josué Simo Louokdon, Exupere Cheugoue Towo, Serge Honoré Tchoukoua, Jonas Kouamouo and K

ABSTRACT

The present survey aimed at identifying the most frequent clinical specimens submitted for analyses and the related susceptibility/resistance profile of Gram-negative rods isolated over a twelve-month period (January 1st through December 31st 2016) at the Université des Montagnes Teaching Hospital, Bangangté, West-Cameroon. All specimen collection, identifications and susceptibility tests were conducted in the Laboratory of Microbiology according to standard protocols recommended by REMIC, 2015 and Eucast-SFM, 2015. Most frequent specimens recorded (87%) were urines, women genital secretions and pus from which close to 88 % of the isolates, overwhelmed by members of the Enterobacteriaceae family were recovered. The most frequent etiologies (Escherichia coli, Enterobacter spp., and Klebsiella spp.) typically predominated in the urine (50% of isolates), followed by the vaginal secretion and pus (19% and 18%, respectively). Overall, the resistance rates to common or related antibacterial agents were higher in Enterobacteriaceae (Ampicillin, 94%; Trimethoprim/Sulfamethoxazole, 64%; Nalidixic acid, 61% and Ciprofloxacin, 43%) while susceptibility ranged from 3% with Amoxicillin/Clavulanic acid to 72% with Imipenem. This trend was also similar in non-fermenting Gram-negative rods, consistent with previous reports. The successive findings could serve as useful clues for effective action towards antibiotic susceptibility/resistance stewardship. To be effective the intervention policy should simultaneously target policy makers, prescribers, and drug users with trained and committed human resources.

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