World Journal of
Pharmaceutical and Life Sciences

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
World Journal of Pharmaceutical and Life Sciences (WJPLS) has indexed with various reputed international bodies like : Google Scholar, Index Copernicus, Indian Science Publications, SOCOLAR, China, Cosmos Impact Factor, Research Bible, Fuchu, Tokyo. JAPAN, Scientific Indexing Services (SIS), Jour Informatics (Under Process), UDLedge Science Citation Index, Global Impact Factor (In Process), International Impact Factor Services, International Scientific Indexing, UAE, International Society for Research Activity (ISRA) Journal Impact Factor (JIF), Science Library Index, Dubai, United Arab Emirates, International Innovative Journal Impact Factor (IIJIF), Scientific Journal Impact Factor (SJIF), Eurasian Scientific Journal Index (ESJI), Indian citation Index (ICI), IFSIJ Measure of Journal Quality, International Scientific Indexing, UAE (ISI), 

Abstract

REVIEW ON ROLE OF BBB AND ITS TRANSPORT MECHANISMS IN THE DEVELOPMENT OF BRAIN TARGETED DRUG DELIVERY SYSTEMS

Adil Patel*

ABSTRACT

The development of brain drug delivery system which can effectively administer drug into brain region has been very challenging for formulation scientists. The presence of highly selective blood brain barrier and tight junction of epithelial cell make the permeation of most drugs difficult. Many researchers have tried to utilize traditional approaches like prodrugs and temporary reversible disruption of blood brain barrier but they are not much effective. Recently the development in the field of nanotechnology has shown some promising results in terms of development of proper brain targeted drug delivery systems. The thorough understanding of underlying mechanism by which some substances are crossing BBB is very important to develop an effective brain targeted drug delivery system. In this review the focus of discussion is on the understanding of various mechanism and effective exploitations of valuable promising leads by which a drug can transport across the BBB to enter into the CNS.

[Full Text Article]

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