World Journal of
Pharmaceutical and Life Sciences

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
World Journal of Pharmaceutical and Life Sciences (WJPLS) has indexed with various reputed international bodies like : Google Scholar, Index Copernicus, Indian Science Publications, SOCOLAR, China, Cosmos Impact Factor, Research Bible, Fuchu, Tokyo. JAPAN, Scientific Indexing Services (SIS), Jour Informatics (Under Process), UDLedge Science Citation Index, Global Impact Factor (In Process), International Impact Factor Services, International Scientific Indexing, UAE, International Society for Research Activity (ISRA) Journal Impact Factor (JIF), Science Library Index, Dubai, United Arab Emirates, International Innovative Journal Impact Factor (IIJIF), Scientific Journal Impact Factor (SJIF), Eurasian Scientific Journal Index (ESJI), Indian citation Index (ICI), IFSIJ Measure of Journal Quality, International Scientific Indexing, UAE (ISI), 

Abstract

FORMULATION AND INVITRO EVALUATION OF LAMIVUDINE FLOATING TABLETS

Syed Gouse Firoz*, Dr. J. N. Suresh Kumar and Shaik Munwar

ABSTRACT

Lamivudine comes under class II drugs according to BCS classification. It is poorly water soluble drug. It has maximum solubility in pH 1.2 and therefore it will be beneficial to retain the drug in stomach for longer period of time for better absorption. It has been reported that conventional release of Lamivudine in stomach causes stomach pain as a side effect. Hence it was found necessary to develop a gastric retentive dosage form containing lamivudine in order to increase the gastric residence time to enhance its absorption and their by its oral bio availability. Also the slow release of the drug in stomach may avoid the stomach pain associated with immediate release of the drug. The aim of our present study was to design, develop and optimize the floating tablets containing lamivudine in order to increase its gastric retention time for enhancing absorption in stomach as well as to produce a controlled release of the drug for a longer time using polymers such as Carbopol, HPMC and Eudragit S 100.

[Full Text Article]

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