World Journal of
Pharmaceutical and Life Sciences

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
World Journal of Pharmaceutical and Life Sciences (WJPLS) has indexed with various reputed international bodies like : Google Scholar, Index Copernicus, Indian Science Publications, SOCOLAR, China, Cosmos Impact Factor, Research Bible, Fuchu, Tokyo. JAPAN, Scientific Indexing Services (SIS), Jour Informatics (Under Process), UDLedge Science Citation Index, Global Impact Factor (In Process), International Impact Factor Services, International Scientific Indexing, UAE, International Society for Research Activity (ISRA) Journal Impact Factor (JIF), Science Library Index, Dubai, United Arab Emirates, International Innovative Journal Impact Factor (IIJIF), Scientific Journal Impact Factor (SJIF), Eurasian Scientific Journal Index (ESJI), Indian citation Index (ICI), IFSIJ Measure of Journal Quality, International Scientific Indexing, UAE (ISI), 

Abstract

FORMULATION AND EVALUATION OF EUDRAGIT RL 100 AND EUDRAGIT RS100 LOADED SESQUITERPENOIDS NANOPARTICLES

A. Abirami*, N. Chidambaranathan, S. Mohammed Halith and M. Nagarajan

ABSTRACT

Objective: ?-Caryophyllene (BCP) is a natural sesquiterpene existing in the essential oil of many plants, has exhibited a wide range of biological activities. However, its volatility and poor water-solubility limit its application in pharmaceutical field. ?-Cyclodextrin (?-CD) has intrinsic ability to form specific inclusion complexes with different drugs to enhance their stability, solubility and bioavailability. The aim of this study is to investigate on the formulation and evaluation of sesquiterpenoid nanoparticles. Methods: Sesquiterpenoid nanoparticles were prepared by solvent evaporation method using Eudragit RL100 and Eudragit RS100 alone and combinations by rotary flash evaporator. These nanoparticles were evaluated for drug entrapement effeciency, invitro release,SEM and zeta potential measurement. Conclusion: In FX formulation the concentration (drug 50mg, Eudragit RL100 15mg, Eudragit RS100 30mg) showed the highest entrapement efficiency 98%. In the FX formulation the percentage of drug release was 99.45% in 24 hours. The optimized formulation was analysed by scanning electrone microscope and stability studies and zetapotential. The sesquiterpenoids nanoparticles exhibited nanometer size ranging from 41.61nm to 77.95nm. and also zeta potential charge.

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