World Journal of
Pharmaceutical and Life Sciences

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
World Journal of Pharmaceutical and Life Sciences (WJPLS) has indexed with various reputed international bodies like : Google Scholar, Index Copernicus, Indian Science Publications, SOCOLAR, China, Cosmos Impact Factor, Research Bible, Fuchu, Tokyo. JAPAN, Scientific Indexing Services (SIS), Jour Informatics (Under Process), UDLedge Science Citation Index, Global Impact Factor (In Process), International Impact Factor Services, International Scientific Indexing, UAE, International Society for Research Activity (ISRA) Journal Impact Factor (JIF), Science Library Index, Dubai, United Arab Emirates, International Innovative Journal Impact Factor (IIJIF), Scientific Journal Impact Factor (SJIF), Eurasian Scientific Journal Index (ESJI), Indian citation Index (ICI), 

Abstract

ZINC AND VITAMIN-E IMPACT ON CADMIUM INDUCED BIOACCUMULATION IN LIVER AND KIDNEY OF MALE ALBINO RAT

Dr. Obaiah Jamakala*

ABSTRACT

Cadmium (Cd) is a toxic, non-essential and industrial pollutant. The aim of the present work is to know the zinc (Zn) and vitamin-E impact on Cd induced bioaccumulation in liver and kidney of Cd treated rats. Wistar strain male albino rats were treated with cadmium chloride at a dose of 1/10th LD50 / 48h i.e. 22.5 mg/Kg body weight for 7, 15 and 30 days (d) time intervals. Then 15d Cd treated rats were divided into three groups. The first group received Zn (12 mg/Kg), second group vitamin-E (300 mg/Kg) alone and third group supplemented with both Zn and vitamin-E for again 7, 15 and 30d long sojourn. After the specific time intervals, rats were decapitated and tested for Cd bioaccumulation levels by Atomic Absorption Spectrophotometer (AAS – Schimadzu AA6300). There was a significant elevation in Cd concentrations in both the test tissues with increased period of Cd treatment. Maximum Cd accumulation was found in 30d Cd treated rat kidney (32.78 ± 0.29?g / gm). However there was a significant reduction in Cd bioaccumulation with Zn and vitamin-E supplementation. Maximum decrease in Cd accumulation was found in 30d rat kidney (8.62±0.15?g / gm) supplemented with the combination of Zn and vitamin-E. Our findings clearly envisage that combined supplementation of Zn and vitamin-E is more effective in reducing the Cd body burden when compared to the other modes of supplementation.

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