World Journal of
Pharmaceutical and Life Sciences

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
World Journal of Pharmaceutical and Life Sciences (WJPLS) has indexed with various reputed international bodies like : Google Scholar, Index Copernicus, Indian Science Publications, SOCOLAR, China, Cosmos Impact Factor, Research Bible, Fuchu, Tokyo. JAPAN, Scientific Indexing Services (SIS), Jour Informatics (Under Process), UDLedge Science Citation Index, Global Impact Factor (In Process), International Impact Factor Services, International Scientific Indexing, UAE, International Society for Research Activity (ISRA) Journal Impact Factor (JIF), Science Library Index, Dubai, United Arab Emirates, International Innovative Journal Impact Factor (IIJIF), Scientific Journal Impact Factor (SJIF), Eurasian Scientific Journal Index (ESJI), Indian citation Index (ICI), 

Abstract

GC-MS ANALYSIS AND ANTIMICROBIAL ACTIVITY OF SUDANESE CASSIA FISTULA LINN (CAESALPINACEAE) FIXED OIL

Dr. Abdel Karim, M.*, Hana K. and Khalid, M. S.

ABSTRACT

Cassia fistula fixed seed oil was studied by GC-MS. The oil was also assessed for antimicrobial activity. Twenty five components were detected by GC-MS analysis. Main constituents are: 9, 12-Octadecadienoic acid methyl ester (24.46%); 9-Octadecenoic acid methyl ester (17.26%); Stigmast-7-en-3-ol (15.75%); Hexadecanoic acid methyl ester(13.55%) and Methyl stearate (7.75%). The antibacterial activity of the oil was evaluated via the diffusion assay against five standard human pathogens (Gram positive: Staphylococcus aureus and Bacillus subtilis; Gram negative: Escherichia coli and Pseudomonasa aeruginosa and the fungus Candida albicans). The oil was active against all test organisms in the range: 100 - 50mg/ml. On the basis of its promising antimicrobial activity, it seems that this oil is a lead for further opimization.

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