World Journal of
Pharmaceutical and Life Sciences

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
World Journal of Pharmaceutical and Life Sciences (WJPLS) has indexed with various reputed international bodies like : Google Scholar, Index Copernicus, Indian Science Publications, SOCOLAR, China, Cosmos Impact Factor, Research Bible, Fuchu, Tokyo. JAPAN, Scientific Indexing Services (SIS), Jour Informatics (Under Process), UDLedge Science Citation Index, Global Impact Factor (In Process), International Impact Factor Services, International Scientific Indexing, UAE, International Society for Research Activity (ISRA) Journal Impact Factor (JIF), Science Library Index, Dubai, United Arab Emirates, International Innovative Journal Impact Factor (IIJIF), Scientific Journal Impact Factor (SJIF), Eurasian Scientific Journal Index (ESJI), Indian citation Index (ICI), IFSIJ Measure of Journal Quality, International Scientific Indexing, UAE (ISI), 

Abstract

ROLE OF LONG NON-CODING RNA CDKN2B-AS1 AND HOMOCYSTEINE IN PATIENTS WITH ISCHEMIC CARDIOMYOPATHY

Azza Elamir*, Khalid El-Khashab, Hassan Ebeid and Hosam Saif El Nasr

ABSTRACT

Background: Ischemic cardiomyopathy (ICM) refers to significantly impaired function of left ventricle that is caused by coronary artery disease. The aim of this study is to assess the levels of lnc-RNA-CDKN2B-AS1 and homocysteine in patients with ischemic cardiomyopathy and compare with patients with non ischemic cardiomyopathy. Methods: The present study was conducted on 86 patients with cardiomyopathy divided into 2 groups: Group I; 56 patients with post-ischemic cardiomyopathy (47 males and 9 Females) and Group II; 30 patients with non ischemic dilated cardiomyopathy (23 males and 7 females). Serum was separated for detection of homocysteine by ELISA and lnc-RNA-CDKN2B-AS1 by qRT-PCR. Results: There was significant increase of serum lnc-RNA-CDKN2B-AS1 in the ischemic group compared with non- ischemic group. Serum Homocysteine level was high in the ischemic group than non- ischemic group but P-value was not significant. Conclusion: Lnc-RNA-CDKN2B-AS1 has a strong potential to act as a biomarker for diagnosis of ischemic cardiomyopathy providing potential new strategies for early screening and treatment of ischemic cardiomyopathy. As regard homocysteine, we need more research to establish it as a risk factor for ischemic cardiomyopathy and this is definitely important for the purpose of strong evidence.

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