World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF TRANEXAMIC ACID AND ETHAMSYLATE PHARMACEUTICAL DOSAGE FORMS

Dr. G. Pratap Kumar*, D. Manjeera and T. Murali Krishna

ABSTRACT

A simple, Accurate, precise method was developed for the simultaneous estimation of the Tranexamic acid and Ethamsylate in Tablet dosage form. Chromatogram was run through Kromasil 250 x 4.6 mm, 5?. Mobile phase containing Buffer and Acetonitrile in the ratio of 55:45A was pumped through column at a flow rate of 1ml/min. Buffer used in this method was 0.1% OPA buffer with pH 4.8 adjusted by Triethylamine and Temperature was maintained at 30°C. Optimized wavelength for Tranexamic acid and Ethamsylate was 230nm. Retention time of Tranexamic acid and Ethamsylate were found to be 2.527min and 3.142 min. %RSD of the Tranexamic acid and Ethamsylate were and found to be 0.9 and 0.1 respectively. %assay was obtained as 100.54% and 99.98% for Tranexamic acid and Ethamsylate respectively. LOD, LOQ values are obtained from regression equations of Tranexamic acid and Ethamsylate were 0.02ppm, 0.08ppm and 0.07ppm, 0.24ppm respectively. Regression equation of Tranexamic acid & Ethamsylate is y = 18625x + 4734and y = 18614x + 5549.Retention times are decreased and that run time was decreased so the method developed was simple and economical that can be adopted in regular Quality control test in Industries.

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