World Journal of
Pharmaceutical and Life Sciences

BIOTRANSFORMATION OF STEROLS BY ACTINOBACTERIA TO PRODUCE PHARMACEUTICAL PRODUCT

Syeda Fareeha Tauheed, Dr. Sikander Ali*, Zannara Mustafa and Sana Ashraf

ABSTRACT

This review consists two parts. In the first part of review we enhance the main aim of the development of pharmaceutical industry by introducing micro biotechnological process on industrial scale and wipeout the many-level chemical coalescence. Also, this article elaborates on the current development of micro sterols biotransformation system. Actinobacteria, which has considerable importance for the production of hormonal drugs (pharmaceutical product) also has main role as a catalyst in the steroid bioconversion and the development of biotechnology. The ability to activate the transformation process of sterol substrate in a broad way, it is feasible to expect the effective use of these microorganism in the advancement of new technologies on the production of pharmaceutical steroids substrate. This article is first attempt to channelize the data on the ability of Actinobacteria to activate the distinct reaction of many biotransformation of steroid such as hydroxylation, reduction and introduction of double bonds, oxidation of steroids, reduction of hydrocarbon (ketones) and degradation, with focus on the importance of biotechnological process and analysis of steroid conversion over the last decade year. The second part of this review precisely emphasis in the location of new enzymatic approaches such as cleavage of steroid side chain.

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