World Journal of
Pharmaceutical and Life Sciences

CANCER STEM CELL GENE VARIANTS AS A MODIFIER IN URINARY BLADDER CANCER PATIENTS

Archana Verma, Rakesh Kapoor, *Dr. Rama Devi Mittal

ABSTRACT

Aim: Cancer stem cell surface markers are potent candidates for various cancers. Therefore, we investigated role of three cancer stem cell markers viz. CD24, CD26 and CD28 in risk prediction and prognosis of bladder cancer (BC) in North India. Results: We analysed CD24, CD26 and CD28 gene polymorphisms in 240 BC patients and 270 controls to find out combinations of genetic variants and confounding risk factors contributing to BC risk. Significant high risk in variant genotype of CD24rs3838646CA/Del (p=0.001), dominant model (p=0.027) as well as in allelic model (p=0.002) and reduced risk was seen in CD26rs7608798T/C (p=0.006, OR=0.572) and the dominant model, TC+CC also revealed reduced risk (p=0.043, OR= 0.695). No association was found based on tumor stage/grade and smoking habit of BC patients as well as those treated with BCG immunotherapy with any of the candidate gene variant. On performing haplotype analysis, we found significant association in one out of four sets with p=0.014; OR=1.615. Gene combination between CD24rs3838646CA/Del and CD26rs7608798T/C showed marginal association with BC risk. Conclusion: Our result suggests that CSC marker gene polymorphism could be used as a marker for risk prediction to BC. However, this study needs to be further validated in other ethnicities.

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