World Journal of
Pharmaceutical and Life Sciences

PHARMACEUTICAL STANDARDIZATION OF ANTI EOSINOPHILIC AYURVEDIC FORMULATION - AQUEOUS EXTRACTS OF HEDYCHIUM SPICATUM [HAM.EX SMITH], SASSUREA LAPPA [C.B.CLARKE], EMBLICA OFFICINALIS [GAERTN] AND CURCUMA LONGA [LINN]

Dr. Sai Prasad A.J.V,* Ratna Manikyam B, NagaLakshmi V, Trimurtulu. G. and Naidu M. L.

ABSTRACT

Pharmaceutical standardisation of anti eosinophilic Ayurvedic formulation capsule is a quadric herbal aqueous extracts combination of Hedychium spicatum (Hamsmithex), Sassurea lappa (C.B.Clarke), Emblica officinalis (Gaertn) and Curcuma longa (Linn). in equal proportions and the ingredients were authenticity by the standard markers, HPTLC finger prints and analytical techniques as for the guidelines of Ayurvedic pharmacopeia of India and WHO. Physicochemical parameters of the formulation shows values of pH 4.53, loss on drying 6.88%, water soluble extractive 87.97%, alcoholic soluble extractive 40.15%, total ash 18.96%, acid. Insoluble ash 0.36%, heavy metal estimation of Lead <5ppm, Cadmium <1 ppm, Arsenic <2 ppm. Phytochemical compound quantification assessed for curcuminoids by spectrometric, tannis by volumetric and total alkaloids by gravimetric methods shows the values of 0.27%, 15.12% and 0.24% respectively. Pharmaceutical standardisation of capsule shows the average net content for capsule 608.60 mg, disintegration time 08min 03 sec, and dissolution of 73.65+0.24.It reveals the standardisation profile for the capsulation of Ayurvedic formulation was in conformity to the properties evaluated for clinical trial on tropical pulmonary eosinophilia in filaria.

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