World Journal of
Pharmaceutical and Life Sciences

SHORT TERM EFFECTS OF FENOTEROL ON CARDIAC MUSCLE OF MICE

Ramesh Kumar, Pooja Sharma* and Sushma Sharma

ABSTRACT

Beta- adrenergic agonists (Fenoterol, Clenbuterol) are sympathomimetic substances which are capable of activating both ?1 and ?2 adrenoceptors in vivo. These drugs produce effects equivalent to those produced as a result of impulses transmitted from postaganglionic fibres of central nervous system. Fenoterol treatment causes a small increase in fatigability due to decrease in oxidative metabolism with some cardiac hypertrophy. Major side effects of fenoterol can be derived from their action at ?2 adrenoceptor and loss of selectivity at higher doses. Thus, tachycardia, tremor, palpitations and nervousness are among the most common adverse events cardiac connective tissue is composed of collagen with small amount of elastin, laminin, fibronectin. Myocardial injury is accompanied by reprative fibrosis. Accumulation of collagen is a characteristic of hypertrophied hearts. The present investigation is an attempt to examine short term effects of fenoterol on major non- contractile apparatus which mainly comprises of collagen in left ventricle. Our present study is carried on short term effect of fenoterol on cardiac muscle of mice. These effects are studied between 2-72 hrs of drug administration. Histopathological examinations have shown the – ve effects of fenoterol on non-contractile machinary of heart. Single dose of fenoterol (2.5mg/kg body wt) has resulted a severe collagen infilteration in the myocardium of left ventricle. These effects results in to disruption of supporting extracellular matrix framework, thereby decreasing ventricular compliance. The myocardial fibrosis observed in left ventricular tissue possibly shows the state of reprative fibrosis, a pathophysiological state.

[Full Text Article]   [Download Certificate]