World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

UV-SPECTROPHOTOMETRIC SIMULTANEOUS DETERMINATION OF IBUPROFEN AND FAMOTIDINE IN COMBINED TABLET DOSAGE FORM

Rajeshri D. Patel*, Prakruti R. Buch, Riddhi H. Shukla, Tejas P. Sharma, Dolly T. Gadhiya and Mihir K. Raval

ABSTRACT

A combination of the Non-Steroidal Anti Inflammatory Drug, Ibuprofen (IBU) and the Histamine H2-receptor antagonist, Famotidine (FAM) is indicated for the relief of signs and symptoms of Rheumatoid Arthritis and Osteoarthritis and to decrease the risk of upper Gastrointestinal ulcers. The aim of the present work was to develop accurate and rapid two UV-Spectrophotometric methods for the simultaneous determination of IBU and FAM in Pharmaceutical formulation. Method A- is simultaneous equation method, wavelengths were selected at 264 nm (?max for IBU) and 287 nm (?max for FAM). Method B- is Absorption ratio method (Q-analysis) using two wavelengths, 271 nm (iso-absorptive point at which both the drugs exhibit absorbance) and 264 nm (?max of IBU). Both the drugs obey the Beer Lambert’s law in the concentration range of 80-640 ?g/ml for IBU and 2-22 ?g/ml for FAM. Method A – the Correlation coefficient (r2 values) of IBU and FAM were found to be 0.9985 and 0.9982 respectively and for Method B the Correlation co-efficient (r2 values) of IBU and FAM were found to be 0.998 and 0.997 respectively. Parameters such as linearity, accuracy, precision, LOD and LOQ values were used for validation of both the methods as per ICH guidelines and can be adopted for the routine analysis of IBU and FAM in pure and tablet dosage form.

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