World Journal of
Pharmaceutical and Life Sciences

EVALUATION OF ACACIA AURICULIFORMIS MUCILAGE AS TABLET BINDER

Bhabani Shankar Nayak*, Sruti Ranjan Mishra, P. Ellaiah, Suchismita Pani and V.V.V.K. Mishra

ABSTRACT

Background: Gums and mucilages have been used as binding agent due to its non toxicity, low cost, emollient, and non irritating agent. The Acacia auriculiformis Linn fruits, family, Leguminaceae, mucilage is used as gum for pasting sheets of paper and card board. Aim: The present study is an attempt to investigate the efficacy of A. auriculiformis fruit mucilage as tablet binder. Methods: The mucilage was screened phytochemically for detection of mucilage and physiochemical characteristics of mucilage were studied. The heavy metal study in soil, study of toxicity, gum-experimental tablet excipients interactions using Fourier transform infrared spectroscopy and Differential Scanning Colorimetry ensured its safe use as a tablet binder. Tablets were manufactured using Paracetamol as model drug and granules were prepared by wet granulation method with different concentration (6, 8, 10, 12 and 14% w/v) of mucilage as tablet binding agent. The prepared granules were evaluated for percentage of fines and flow properties. A comparison was made against the tablets prepared with 10 % w/v poly vinyl pyrrolidone paste as standard binder, based on studying the standard parameters like hardness, thickness, friability, weight variation, disintegration time and in vitro dissolution. Results: The tablets had good tablet physiochemical properties and the drug release was more than 99 % within 1.8 h. A. auriculiformis at 10 % w/v was found to be effective as tablet binder. All the formulations were subjected to stability studies and showed stable with respect to tablet parameters. Conclusion: Thus A. auriculiformis gum will be a non-toxic, biodegradable, economic and easily available option as tablet binder.

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