World Journal of
Pharmaceutical and Life Sciences

A HOSPITAL-BASED STUDY ON STATUS OF SERUM ANTI-MÜLLERIAN HORMONE AMONG WOMEN IN EASTERN NEPAL

Shripad J. Walavalkar, Prerna Dahal, Apeksha Niraula, Guddi Das, Ram L. Mallick*

ABSTRACT

Anti-müllerian hormone is homodimeric glycoprotein that belongs to the super-family of transforming growth factor-?. Sertoli cells of fetal testes produce anti-müllerian hormone. Production of anti-müllerian hormone by testes and thereby regression of müllerian ducts of female reproductive tract called sex-dimorphic expression pattern, however is lost after birth and granulosa cells of growing follicles in ovary express anti-müllerian hormone. Ovarian reserve constitutes the size of follicle pool and the quality of oocytes therein. The ovarian reserve declines as age advances and so decreases woman’s reproductive usefulness. Serum levels of anti-müllerian hormone thus indicate size of the growing follicular pool. Further, anti-müllerian hormone is detectable in serum and, therefore, exist as a promising candidate. In spite of its crucial use in ovarian assessment, status of serum anti-müllerian hormone levels in Nepalese women was still unknown. Thus we determined status of circulating levels of anti-müllerian hormone in local women. In the present study, we found that around 70 % females were < 35-years-old and the bulk of subjects had serum anti-müllerian hormone concentrations within reference range. Moreover, comparative analysis showed that the subjects < 35-years-old had higher serum anti-müllerian hormone levels compared to population > 35, and a significant difference was present therein.

[Full Text Article]   [Download Certificate]