World Journal of
Pharmaceutical and Life Sciences

GC-MS ANALYSIS AND ANTIMICROBIAL ACTIVITY OF SUDANESE PETROSELINUM CRISPUM(MILL) NYMAN EX AW HILL (APIACEAE) ESSENTIAL OIL

Abdel Karim. M.*, Weam, A.K. and Yasir Waleed

ABSTRACT

Information on the phytoconstituents of medicinal plants used traditionally in Sudan is very scarce. Hence this study was set to investigate the chemical constituents of the medicinally important species Petroselinum crispum oil and to evaluate its potential antimicrobial activity. 47 components were detected by GC-MS analysis being dominated by: apiol (38.28%); 4-methoxy-6-(2-propenyl)-1,3-enzodioxole(28.82%); 1,2,3-trimethoxy-5-(2-propenyl)benzene(6.63%); 2,6,6-trimethyl-bicycl[3.1.1]heptane(6.31%). The antibacterial activity of the oil was evaluated via cup plate agar diffusion bioassay against six standard human pathogens(Gram positive: Staphylococcus aureus and Bacillus subtilis; Gram negative: Escherichia coli and Pseudomonasa aeruginosa and the fungi Candida albicans and Aspergillus niger). The oil showed activity only against Staphylococcus aureus. It seems that the oil is a lead for further optimization.

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